전사인자와 coregulators (coactivators & corepressors)는 유전자 발현을 조절하는 핵심 조절자들로서 발생, 성장, 분화 등 정상 세포의 생리활성 유지뿐만 아니라 암 발생 및 진행에도 중요한 역할을 함. 본 연구실은 다양한 분자세포생물학 (molecular cell biology), 생화학 (biochemistry), 후성유전학 (epigenetics)적 방법을 사용하여 새로운 coregulators를 발굴 및 동정하고 암 발생과 진행에 관련된 그들의 작용 기전 및 임상적 의의를 크로마틴 구조변화 (chromatin remodeling), 단백질 변형 (post-translational modifications), 새로운 전사조절 coregulator pathway등 분자 수준에서 규명하는 것을 연구 목표로 삼고 있음. 이와 같은 연구는 유전자 발현조절에 대한 분자 기전의 이해뿐만 아니라 다양한 생물학적 현상 및 병태생리 기전을 이해하는데 필수적인 기초 지식을 제공하고 또한 질병치료를 위한 새로운 치료표적으로서 신약개발에 적극 활용되고 있음.
학력
(Ph.D.) 2000 ~ 2004 이학박사, University of Southern California, 병리과
약력/경력
1993 ~ 2000 선임연구원, 중외제약 C&C신약연구소
2004 ~ 2009 Post-doc, 미국 University of Southern California, 생화학분자생물학과
2009 ~ 2011 조교수 삼성서울병원, 삼성미래의학연구원
2012 ~ 현재 부교수 성균관대학교 삼성융합의과학원
학술지 논문
(2023)
Mechanistic insights into the dual role of CCAR2/DBC1 in cancer.
EXPERIMENTAL AND MOLECULAR MEDICINE.
55,
8
(2022)
DBC1 is a key positive regulator of enhancer epigenomic writers KMT2D and p300.
NUCLEIC ACIDS RESEARCH.
50,
14
(2021)
Sequence variants in the proximal promoter and+5.8-kb site of ABO in Koreans with weak B phenotypes.
VOX SANGUINIS.
epub,
epub
(2021)
Bruceantin targets HSP90 to overcome resistance to hormone therapy in castration-resistant prostate cancer.
THERANOSTICS.
11,
2
(2020)
Medicinal Activities and Nanomedicine Delivery Strategies for Brucea javanica Oil and Its Molecular Components.
MOLECULES.
25,
22
(2019)
Detection of circulating tumor cells and their potential use as a biomarker for advanced renal cell carcinoma.
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL.
13,
9
(2018)
DBC1 regulates Wnt/beta-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer.
CELL DEATH & DISEASE.
9,
8
(2018)
DBC1 promotes castration-resistant prostate cancer by positively regulating DNA binding and stability of AR-V7.
ONCOGENE.
37,
10
(2018)
DBC1 promotes castration-resistant prostate cancer by positively regulating DNA binding and stability of AR-V7..
ONCOGENE.
37,
10
(2016)
Immunohistochemical staining of ERG and SOX9 as potential biomarkers of docetaxel response in patients with metastatic castration-resistant prostate cancer.
ONCOTARGET.
7,
50
(2016)
Positive regulation of beta-catenin-PROX1 signaling axis by DBC1 in colon cancer progression.
ONCOGENE.
35,
26
(2016)
Expression of DBC1 is associated with poor prognosis in hepatitis virus-related hepatocellular carcinoma.
PATHOLOGY RESEARCH AND PRACTICE.
212,
7
(2016)
The Overexpression of CCAR1 in Hepatocellular Carcinoma Associates with Poor Prognosis.
CANCER RESEARCH AND TREATMENT.
48,
3
(2015)
Positive regulation of β-catenin-PROX1 signaling axis by DBC1 in colon cancer progression.
ONCOGENE.
Epub,
Epub
(2015)
The Overexpression of CCAR1 in Hepatocellular Carcinoma Associates with Poor Prognosis.
CANCER RESEARCH AND TREATMENT.
Epub,
Epub
(2015)
A positive role of DBC1 in PEA3-mediated progression of estrogen receptor-negative breast cancer.
ONCOGENE.
34,
34
(2014)
A positive role of DBC1 in PEA3-mediated progression of estrogen receptor-negative breast cancer.
ONCOGENE.
epub,
epub
(2014)
The prognostic significance of Smad3, Smad4, Smad3 phosphoisoform expression in esophageal squamous cell carcinoma.
MEDICAL ONCOLOGY.
31,
11
(2014)
ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, promotes esophageal squamous cell carcinoma.
ONCOTARGET.
5,
23
(2014)
Overexpression of integrin alpha v correlates with poor prognosis in colorectal cancer.
JOURNAL OF CLINICAL PATHOLOGY.
67,
7
특허/프로그램
브루세안틴(Bruceantin) 및 나노입자를 포함하는 거세 저항성 전립선암 치료용 약학적 조성물(A pharmaceutical composition for treating castration-resistant prostate cancer comprising bruceantin and nanoparticles).
10-2626-6930000.
20240115.
대한민국
수상/공훈
Pre-doctoral Breast Cancer Research Fellowship Award, USC/Norris comprehensive cancer center, 2000-2004
Post-doctoral traineeship Award T32 CA009320 from NIH, 2006-2009
(2022)
DBC1 is a key positive regulator of enhancer epigenomic writers KMT2D and p300.
2022년도 KSMCB 에피유전체학분과 심포지엄.
대한민국
(2022)
Role of DBC1 in the regulation of histone H3 acetylation and methylation.
KSBMB International Conference 2022.
대한민국
(2017)
DBC1, a regulator of nuclear receptors and epigenetic modifiers.
2017년 KSMCB 에피유전체학분과 심포지움.
대한민국
(2017)
DBC1 promotes castration-resistant prostate cancer by positively regulating DNA binding and stability of AR-V7.
2017년 대한전립선학회,대한비뇨기종양학회,비뇨기계기초의학연구회 공동심포지움.
대한민국
(2014)
Regulation of PEA3 acetylation by DBC1.
The 21st East Asia Joint Symposium on Biomedical Research.
대한민국
(2012)
SUMOylation of ZFP282 potentiates its positive effect on estrogen signaling in breast tumorigenesis.
2012년도 한국분자세포생물학회 정기학술대회.
대한민국
